CZ:Ref:DOI:10.1002/hbm.10062

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Smith SM (2002). "Fast robust automated brain extraction". Hum Brain Mapp 17 (3): 143-55. DOI:10.1002/hbm.10062. PMID 12391568. Research Blogging. [e]

The theoretical basis for the popular FSL BET package for brain extraction from neuroimaging data, with the following basic processing steps:
  1. Binarization of the image based on a threshold estimated from the histogram
  2. Determination of centre of gravity of the binary image and of the radius of a sphere with a volume equivalent to the number of above-threshold voxels
  3. Initialization of a tesselated surface of a sphere with half that radius
  4. Surface growing until the enclosed volume reaches the size of the full sphere and is topologically correct
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